What is Guanfacine?

Guanfacine is an oral, centrally-acting, alpha2-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension (high blood pressure).

It works by producing a decrease in sympathetic outflow, resulting in a reduction in peripheral vascular resistance, renal vascular resistance, heart rate, and blood pressure.

Guanfacine is similar to clonidine but is more selective for alpha2-adrenergic receptors, longer acting, dosed once daily, and has less frequency and severity of rebound hypertension following abrupt discontinuation.

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